Location: Changping District, Beijing Investigator/Senior Investigator, Molecular/Cellular Biology
Responsibilities: 1.You will review the literature independently; perform studies on disease biology and the mechanism of action of therapeutics; and facilitate drug design and development by participating in evaluations of new directions, new targets and program establishment 2.By working independently and/or by leading a team, you will design, establish and optimize molecular, biochemical and cellular screening methods in order to evaluate concepts or hypotheses, and perform drug efficacy studies in a timely fashion according to project needs 3.You will execute experiments, collect and process data, record results in laboratory notebooks, write reports and present to bigger teams Requirements: 1.PhD (or MS with at least 2 years of experience in drug development) in molecular biology, cell biology, biochemistry, immunology, pharmacology or related fields 2.Extensive experience and deep understanding of the following molecular or cellular technologies: molecular cloning, tissue culture, transfection, transformation, establishment of cell lines with gene over-expression or knock-out, flow cytometry, western blotting, RT-qPCR, immunofluorescence, ELISA and lentivirus packaging 3.Expertise in one or more of the following will be a plus: 1)Gene modification technology (CRISPR, RNAi, ASO, mRNA, etc.) 2)Protein expression and purification, antibody discovery by hybridoma, phage or yeast display, or single B cell technologies 3)HTRF/AlphaLisa/ADP-Glo/ELISA 4)Culture of primary cells, stem cells or organoids 5)Immunology assays (cytotoxic assay, ELISpot, etc.) 6)High-content screening or life-imaging, and data analysis 7)In vivo studies: immunology and/or oncology animal models, PK/PD studies 4.Proficient in relevant software packages, including Word, Excel, PowerPoint, GraphPad 5.Solid backgrounds in biology and research training, a quick learner 6.Fluent in verbal and written English 7.Responsible, detail-orientated, innovative, handles challenges and pressure well, good communication skills and strong team-work spirit Investigator, Drug Delivery
Responsibilities:
1.By working independently and/or leading a team, you will design, establish and optimize cell lines, and test/screen methods for drug delivery in vivo; you will also perform studies to evaluate drug delivery efficiency and safety in a timely fashion according to project needs
2.You will perform studies on disease biology and the underlying mechanisms to provide foundations for other programs
3.You will review the literature independently, and participate in explorations of novel mechanisms
4.You will be responsible for executing experiments, collecting and processing data, recording results in laboratory notebooks, writing reports and presenting to bigger teams
5.You will participate in evaluations of new directions, new targets and program establishment
Requirements:
1.PhD or MS in molecular biology, cell biology, biochemistry, immunology, pharmacology or related fields; at least 1 year (PhD) or 3 years (MS) of work experience (including postdoctoral experience); industrial experience in large or small molecule drug development preferred
2.Working experience and deep understanding of the establishment, characterization of physiochemical properties and evaluation of delivery efficiency using at least one of the established drug delivery systems (such as LNP, polymer or exosome delivery systems)
3.Experience/expertise in one or more of the following will be a plus:
a)Design and evaluation of targeted drug delivery systems
b)Synthesis/purification of peptides; production/purification of antibodies
c)Delivery of nucleotide therapeutics
d)Design and optimization of membrane structures (membrane fusion, modifications)
e)High-content screening or life-imaging, and data analysis
f)In vivo studies: immunology and/or oncology animal models, PK/PD studies
4.Proficient in relevant software packages, including Word, Excel, PowerPoint, GraphPad.
5.Solid backgrounds in biology and research training, a quick learner
6.Fluent in verbal and written English
7.Responsible, detail-orientated, innovative, handles challenges and pressure well, good communication skills and strong team-work spirit Associate Director/Director/Senior Director/Executive Director/VP, Drug Delivery
Responsibilities: 1.You will be responsible for the development direction, evaluation and program establishment in drug delivery, and you will be responsible for and/or drive the design and development of the delivery pipeline 2.You will be responsible for planning and executing the development strategy for the delivery pipeline, overseeing and/or driving all studies supporting delivery pipeline therapeutics, delivery of key data to facilitate external collaboration and all material, reports supporting IND filing with high quality in a timely fashion 3.You will lead a team of scientists to design, establish and optimize molecular, cellular and animal studies in drug delivery; you will also be responsible for overseeing/monitoring data processing, recording of results in laboratory notebooks, writing reports and presenting to bigger teams/management 4.You will drive or facilitate external collaborations in the drug delivery field 5.You will serve as a subject matter expert, and you will provide theoretical and experimental support and guidance for other development programs in the company 6. You will participate in company decision-making, and you will represent the company as the delivery expert in scientific meetings, discussions, communications and roadshows as needed Requirements: 1.PhD or MS in molecular biology, cell biology, biochemistry, immunology, pharmacology or related fields; at least 2 years (PhD) or 5 years (MS) of drug development experience in drug delivery; industrial experience, especially with management experience, preferred 2.Familiar with the entire drug development process in current drug delivery systems; experience in IND and/or NDA filing is a plus 3.Solid track record of biology and research training and productivity; a proven quick learner 4.Extensive working experience and deep understanding of the relevant literature and experimental technologies in drug delivery; working experience with in vivo animal models of drug deliveries is a plus 5.Fluent in verbal and written English; good communication and leadership skills 6.Responsible, detail-orientated, innovative, handles challenges and pressure well, and strong team-work spirit Submit CV
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